The Ministry of Defence of Ukraine is the ministry of the Ukrainian government that oversees national defence and the Armed Forces of Ukraine. The head of the ministry is the Minister of Defence. The President of Ukraine is the Supreme Commander-in-Chief of the Armed Forces of Ukraine.

A ministry of defence or defense, also known as a department of defence or defense, is the part of a government responsible for matters of national defence and military forces, found in states where the government is divided into ministries or departments. Such a department usually includes all branches of the military, and is usually controlled by a defence minister or secretary of defense.