The Ministry of the Interior of Argentina is a ministry of the national executive power that manages issues pertaining to domestic politics such as immigration and co-ordination between the federal government and the governments of the provinces of Argentina.

The Ministries of the Argentine Republic, which form the cabinet, currently consist of nine ministries under a ministerial chief of staff. The ministers are appointed by and serve at the pleasure of the president. The current organization derives from the constitutional revision of 1994, and is governed by "The Law on Ministries".