Minnesota State Highway 44 is a highway in southeast Minnesota, which runs from its intersection with U.S. 52 in Canton Township, near Prosper, and continues east to its eastern terminus at its intersection with State Highway 16 in Hokah, near La Crescent.

U.S. Highway 52 (US 52) enters the state of Minnesota at the unincorporated community of Prosper, north of the town of Burr Oak, Iowa. The route is marked north–south in Minnesota along its independent segment from the Iowa state line to downtown St. Paul. US 52 is not signed along the length of its concurrency with Interstate 94 (I-94) from downtown St. Paul to the North Dakota state line at Moorhead and Fargo.