Mir was a space station that operated in low Earth orbit from 1986 to 2001, operated by the Soviet Union and later by Russia. Mir was the first modular space station and was assembled in orbit from 1986 to 1996. It had a greater mass than any previous spacecraft. At the time it was the largest artificial satellite in orbit, succeeded by the International Space Station (ISS) after Mir's orbit decayed. The station served as a microgravity research laboratory in which crews conducted experiments in biology, human biology, physics, astronomy, meteorology, and spacecraft systems with a goal of developing technologies required for permanent occupation of space.

Humans have been present in space either, in the common sense, through their direct presence and activity like human spaceflight, or through mediation of their presence and activity like with uncrewed spaceflight, making "telepresence" possible. Human presence in space, particularly through mediation, can take many physical forms from space debris, uncrewed spacecraft, artificial satellites, space observatories, crewed spacecraft, art in space, to human outposts in outer space such as space stations. While human presence in space, particularly its continuation and permanence can be a goal in itself, human presence can have a range of purposes and modes from space exploration, commercial use of space to extraterrestrial settlement or even space colonization and militarisation of space. Human presence in space is realized and sustained through the advancement and application of space sciences, particularly astronautics in the form of spaceflight and space infrastructure.