Mishkenot Sha'ananim was the first Jewish settlement built outside the walls of the Old City of Jerusalem, on a hill directly across Mount Zion. It was built in 1859–1860. This guesthouse was one of the first structures to be built outside the Old City, the others being Kerem Avraham, the Schneller Orphanage, Bishop Gobat school, and the Russian Compound.

The Old City of Jerusalem is a 0.9-square-kilometre (0.35 sq mi) walled area in East Jerusalem.