Misiones is one of the 23 provinces of Argentina, located in the northeastern corner of the country in the Mesopotamia region. It is surrounded by Paraguay to the northwest, Brazil to the north, east and south, and Corrientes Province of Argentina to the southwest.

The Paraguayan War, also known as the War of the Triple Alliance, was a South American war that lasted from 1864 to 1870. It was fought between Paraguay and the Triple Alliance of Argentina, the Empire of Brazil, and Uruguay. It was the deadliest and bloodiest inter-state war in Latin American history. Paraguay sustained large casualties, but the approximate numbers are disputed. Paraguay was forced to cede disputed territory to Argentina and Brazil. The war began in late 1864, as a result of a conflict between Paraguay and Brazil caused by the Uruguayan War. Argentina and Uruguay entered the war against Paraguay in 1865, and it then became known as the "War of the Triple Alliance."