The Miss Missouri USA competition is the pageant that selects the representative for the state Missouri in the Miss USA pageant. It is directed by Vanbros and Associates, based in Lenexa, Kansas. In 1993, Missouri joined the Vanbros group of state pageants for the Miss USA and Teen USA system.

Miss USA is an American beauty pageant that has been held annually since 1952 to select the entrant from United States in the Miss Universe pageant. The Miss Universe Organization operated both pageants, as well as Miss Teen USA, until 2020, when the organization announced it was licensing operation of the Miss USA and Miss Teen USA pageants to Crystle Stewart, Miss USA for 2008 prior to her suspension in October 2022, thus returning the said pageants to the Miss Universe Organization.