Miss Universe 2010 was the 59th Miss Universe pageant, held at the Mandalay Bay Events Center in Las Vegas, Nevada, United States on August 23, 2010.

The Michelob Ultra Arena, formerly the Mandalay Bay Events Center, is a 12,000-seat multi-purpose indoor arena at the Mandalay Bay Resort and Casino, located on the Las Vegas Strip in Paradise, Nevada. It is owned and operated by MGM Resorts International, and was opened on April 10, 1999. MGM and brewing company Anheuser-Busch entered a naming-rights agreement in 2021, naming the arena after the company's Michelob Ultra beer.