The Missile Defense Agency (MDA) is a component of the United States government's Department of Defense responsible for developing a comprehensive defense against ballistic missiles. It had its origins in the Strategic Defense Initiative (SDI) which was established in 1983 by Ronald Reagan and which was headed by Lt. General James Alan Abrahamson. Under the Strategic Defense Initiative's Innovative Sciences and Technology Office headed by physicist and engineer Dr. James Ionson, the investment was predominantly made in basic research at national laboratories, universities, and in industry. These programs have continued to be key sources of funding for top research scientists in the fields of high-energy physics, advanced materials, nuclear research, supercomputing/computation, and many other critical science and engineering disciplines—funding which indirectly supports other research work by top scientists, and which was most politically viable to fund from appropriations for national defense. It was renamed the Ballistic Missile Defense Organization in 1993, and then renamed the Missile Defense Agency in 2002. The current director is U.S. Navy Vice Admiral Jon A. Hill.

The United States Department of Defense is an executive branch department of the federal government of the United States charged with coordinating and supervising all agencies and functions of the U.S. government directly related to national security and the United States Armed Forces. As of June 2022, the U.S. Department of Defense is the largest employer in the world, with over 1.34 million active-duty service members, including soldiers, marines, sailors, airmen, and guardians. The Department of Defense also maintains over 778,000 National Guard and reservists, and over 747,000 civilians bringing the total to over 2.87 million employees. Headquartered at the Pentagon in Arlington County, Virginia, just outside Washington, D.C., the Department of Defense's stated mission is to provide "the military forces needed to deter war and ensure our nation's security".