Mission Health, based in Asheville, North Carolina, is the state's sixth-largest health system, serving much of western North Carolina. A sale to HCA Healthcare became final on February 1, 2019, in which it was sold as a nonprofit to a for-profit company. The proceeds went to a nonprofit foundation, the Dogwood Health Trust, which plans to distribute annual grants focused on healthcare.

Angel Medical Center is a hospital located in Franklin, North Carolina certified by the United States Department of Health and Human Services. The hospital is licensed for 30 beds, plus a 17-bed emergency department.