The Qu'Appelle River is a river in the Canadian provinces of Saskatchewan and Manitoba that flows 430 kilometres (270 mi) east from Lake Diefenbaker in south-western Saskatchewan to join the Assiniboine River in Manitoba, just south of Lake of the Prairies, near the village of St. Lazare. It is in a region called the Prairie Pothole Region of North America, which extends throughout three Canadian provinces and five U.S. states. It is also within Palliser's Triangle and the Great Plains ecoregion.