Mission Nombre de Dios is a Catholic mission founded in 1565 in St. Augustine, Florida, on the west side of Matanzas Bay. It is part of the Diocese of St. Augustine and is likely the oldest extant mission in the continental United States. The National Shrine of Our Lady of La Leche, the oldest shrine in that region, is located on the mission grounds.

Pedro Menéndez de Avilés was a Spanish admiral, explorer and conquistador from Avilés, in Asturias, Spain. He is notable for planning the first regular trans-oceanic convoys, which became known as the Spanish treasure fleet, and for founding St. Augustine, Florida, in 1565. This was the first successful European settlement in La Florida and the most significant city in the region for nearly three centuries.