Mission Nuestra Señora de la Soledad, commonly known as Mission Soledad, is a Spanish mission located in Soledad, California. The mission was founded by the Franciscan order on October 9, 1791, to convert the Native Americans living in the area to Catholicism. It was the thirteenth of California's Spanish missions, and is named for Mary, Our Lady of Solitude. The town of Soledad is named for the mission.

The Spanish missions in California formed a series of 21 religious outposts or missions established between 1769 and 1833 in what is now the U.S. state of California. The missions were established by Catholic priests of the Franciscan order to evangelize indigenous peoples backed by the military force of the Spanish Empire. The missions were part of the expansion and settlement of New Spain through the formation of Alta California, expanding the empire into the most northern and western parts of Spanish North America. Civilian settlers and soldiers accompanied missionaries and formed settlements like the Pueblo de Los Ángeles.