Mission San Francisco de la Espada is a Roman Rite Catholic mission established in 1690 by Spain and relocated in 1731 to present-day San Antonio, Texas, in what was then known as northern New Spain. The mission was built in order to convert local Native Americans to Christianity and solidify Spanish territorial claims in the New World against encroachment from France. Today, the structure is one of four missions that comprise San Antonio Missions National Historical Park.

Franciscan Friars established Mission Nuestra Señora de la Purísima Concepción de Acuña in 1711 as Nuestra Señora de la Purísima Concepción de los Hainais in East Texas. The mission was by the Domingo Ramón-St. Denis expedition and was originally meant to be a base for converting the Hasinai to Catholicism and teaching them what they needed to know to become Mexican citizens. The friars moved the mission in 1731 to San Antonio. After its relocation most of the people in the mission were Pajalats who spoke a Coahuiltecan language. Catholic Mass is still held at the mission every Sunday.