Mission San Luis Obispo de Tolosa is a Spanish mission founded September 1, 1772 by Father Junípero Serra in San Luis Obispo, California. Named after Saint Louis of Anjou, the bishop of Toulouse, the mission is the namesake of San Luis Obispo.

San Luis Obispo is a city and county seat of San Luis Obispo County, in the U.S. state of California. Located on the Central Coast of California, San Luis Obispo is roughly halfway between the San Francisco Bay Area in the north and Greater Los Angeles in the south. The population was 47,063 at the 2020 census.