Mississippi's 2nd congressional district (MS-2) covers much of Western Mississippi. It includes most of Jackson, the riverfront cities of Greenville, Natchez and Vicksburg and the interior market cities of Clarksdale, Greenwood and Clinton. The district is approximately 275 miles (443 km) long, 180 miles (290 km) wide and borders the Mississippi River; it encompasses much of the Mississippi Delta, for a total of 28 counties plus parts of Hinds and Madison. It is the only majority-black district in the state. With a Cook Partisan Voting Index rating of D+11, it is also the only Democratic district in Mississippi.

Jackson is the capital of and the most populous city in the U.S. state of Mississippi. Along with Raymond, Jackson is one of two county seats for Hinds County. The city had a population of 153,701 at the 2020 census, a significant decline from 173,514, or 11.42%, since the 2010 census, representing the largest decline in population during the decade of any major U.S. city. Jackson is the anchor for the Jackson metropolitan statistical area, the largest metropolitan area located entirely in the state and the tenth-largest urban area in the Deep South. With a 2020 population of nearly 600,000, metropolitan Jackson is home to over one-fifth of Mississippi's population. The city sits on the Pearl River and is located in the greater Jackson Prairie region of Mississippi. Jackson is the only city in Mississippi with a population exceeding 100,000 people.