Mississippi's 4th congressional district covers the southeastern region of the state. It includes all of Mississippi's Gulf Coast, stretching ninety miles between the Alabama border to the east and the Louisiana border to the west, and extends north into the Pine Belt region. It includes three of Mississippi's four most heavily populated cities: Gulfport, Biloxi, and Hattiesburg. Other major cities within the district include Bay St. Louis, Laurel, and Pascagoula. The district is currently represented by Republican Mike Ezell. With a Cook Partisan Voting Index rating of R+22, it is the most Republican district in Mississippi.

Mississippi's 3rd congressional district (MS-3) covers central portions of state and stretches from the Louisiana border in the west to the Alabama border in the east.