Mississippi's 4th congressional district covers the southeastern region of the state. It includes all of Mississippi's Gulf Coast, stretching ninety miles between the Alabama border to the east and the Louisiana border to the west, and extends north into the Pine Belt region. It includes three of Mississippi's four most heavily populated cities: Gulfport, Biloxi, and Hattiesburg. Other major cities within the district include Bay St. Louis, Laurel, and Pascagoula. The district is currently represented by Republican Mike Ezell. With a Cook Partisan Voting Index rating of R+22, it is the most Republican district in Mississippi.

Walter Michael Ezell is a former American law enforcement officer and politician serving as the U.S. representative for Mississippi's 4th congressional district since 2023. He is a member of the Republican Party.