Mississippi Highway 1 is a state highway in Mississippi that runs south from U.S. Highway 49 near Lula to U.S. Highway 61 south of Cary, roughly paralleling the Mississippi River. It travels approximately 148 miles (238 km), serving Sharkey, Issaquena, Washington, Bolivar, and Coahoma Counties. The entire route is part of the Great River Road and lies entirely within the Mississippi Delta region.

Issaquena County is a county located in the U.S. state of Mississippi. As of the 2020 Census, its population was 1,338, making it the least populous county in the United States east of the Mississippi River. Its county seat is Mayersville. With a per-capita income of $18,598, Issaquena County is, by that measure, one of the poorest counties in the United States.