Mississippi Highway 2 is a designation for two highways in northern Mississippi. The westernmost segment starts at MS 5 in Hickory Flat, and ends at MS 15 and MS 368 in Blue Mountain. The eastern segment starts at MS 4 near Ripley and it travels northeastwards towards Corinth. The route becomes concurrent with U.S. Route 72 and US 45 in Corinth, and ends at the Tennessee state line. The road continues as Tennessee State Route 22. The route was designated around 1932, from the state line near Mount Pleasant to the state line near Corinth. The section west of Corinth became a part of US 72 by 1935, and the route was extended southwestwards to Hickory Flat by 1958.

Mississippi Highway 5 is a state highway in Benton County, Mississippi, United States. It runs 24.3 mi (39.107 km) from MS 178 in Hickory Flat north to U.S. Route 72 to the south of Michigan City. The route runs through the Holly Springs National Forest for much of its length and passes through Ashland. To the south of Ashland, MS 5 has a concurrency with MS 4. The MS 5 designation was first used by 1932 for an unpaved road between Hickory Flat and the Tennessee border in Michigan City. In 1943, the northern terminus was cut back to US 72. MS 5 was completely paved by 1951 and has retained its current alignment since then.