Mississippi Highway 21 is a state highway in central Mississippi. It runs from north to south for 80.3 miles (129.2 km) and serves six counties: Scott, Leake, Newton, Neshoba, Kemper, and Noxubee.

Scott County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 27,990. Its county seat is Forest. The county is named for Abram M. Scott, the Governor of Mississippi from 1832 to 1833.