Mississippi Highway 22 is a state highway in central Mississippi, United States. It runs from east to west for approximately 43 miles (69 km), serving only two counties: Madison and Hinds, while connecting the towns of Edwards, Flora, and Canton.

Madison County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 109,145. The county seat is Canton. The county is named for Founding Father and U.S. President James Madison.