Mississippi Highway 301 is a north-south state highway in northwestern Mississippi. It runs from the community of Arkabutla in Tate County, north across Arkabutla Dam, to the Tennessee border in DeSoto County, where it continues as Tennessee State Route 175.

Arkabutla Lake is a reservoir on the Coldwater River in the U.S. state of Mississippi. It was created following the construction of the Arkabutla Dam in 1940 on the Coldwater River.