Mississippi Highway 5 is a state highway in Benton County, Mississippi, United States. It runs 24.3 mi (39.107 km) from MS 178 in Hickory Flat north to U.S. Route 72 to the south of Michigan City. The route runs through the Holly Springs National Forest for much of its length and passes through Ashland. To the south of Ashland, MS 5 has a concurrency with MS 4. The MS 5 designation was first used by 1932 for an unpaved road between Hickory Flat and the Tennessee border in Michigan City. In 1943, the northern terminus was cut back to US 72. MS 5 was completely paved by 1951 and has retained its current alignment since then.

Benton County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 7,646. Its county seat is Ashland.