Mississippi Highway 8 is an east–west state highway in northern Mississippi, running 168.1 miles (270.5 km) from MS 1 in Rosedale to U.S. Route 278 northeast of Aberdeen. Points of interest along the route include Great River Road State Park, Delta State University, Grenada Lake, Hugh White State Park, and the Natchez Trace Parkway.

Mississippi Highway 1 is a state highway in Mississippi that runs south from U.S. Highway 49 near Lula to U.S. Highway 61 south of Cary, roughly paralleling the Mississippi River. It travels approximately 148 miles (238 km), serving Sharkey, Issaquena, Washington, Bolivar, and Coahoma Counties. The entire route is part of the Great River Road and lies entirely within the Mississippi Delta region.