Mississippi Industrial College was a historically black college in Holly Springs, Mississippi. It was founded in 1905 by the Mississippi Conference of the Colored Methodist Episcopal Church. After desegregation of community colleges in the mid-20th century, it had trouble competing and eventually closed in 1982. The campus was listed as a historic site on the National Register of Historic Places in 1980 and was acquired by Rust College in 2008.

Holly Springs is a city in, and the county seat of, Marshall County, Mississippi, United States, near the border with Tennessee to the north. As of the 2020 census, the population was 6,968, down from 7,699 in 2010. Along with the Mississippi Delta, in the 19th century, the area was developed by European Americans for cotton plantations. After the Civil War, many freedmen continued to work in agriculture as sharecroppers and tenant farmers.