The Mississippi River Delta is the confluence of the Mississippi River with the Gulf of Mexico in Louisiana, southeastern United States. The river delta is a three-million-acre area of land that stretches from Vermilion Bay on the west, to the Chandeleur Islands in the east, on Louisiana's southeastern coast. It is part of the Gulf of Mexico and the Louisiana coastal plain, one of the largest areas of coastal wetlands in the United States. The Mississippi River Delta is the 7th largest river delta on Earth (USGS) and is an important coastal region for the United States, containing more than 2.7 million acres of coastal wetlands and 37% of the estuarine marsh in the conterminous U.S. The coastal area is the nation's largest drainage basin and drains about 41% of the contiguous United States into the Gulf of Mexico at an average rate of 470,000 cubic feet per second.

The Mississippi River is the primary river, and second-longest river, of the largest drainage basin in the United States. From its traditional source of Lake Itasca in northern Minnesota, it flows generally south for 2,340 miles (3,766 km) to the Mississippi River Delta in the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains all or parts of 32 U.S. states and two Canadian provinces between the Rocky and Appalachian mountains. The main stem is entirely within the United States; the total drainage basin is 1,151,000 sq mi (2,980,000 km2), of which only about one percent is in Canada. The Mississippi ranks as the thirteenth-largest river by discharge in the world. The river either borders or passes through the states of Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana.