The Mississippi River & Bonne Terre Railway was a single-track standard-gauge steam railroad that was located in southeastern Missouri and began service in 1892. It extended from Riverside in a general southwesterly direction to the lead-mining field in St. Francois County. The main stem, from Riverside to Doe Run, was 46.492 miles (74.822 km) long. Eight short branch lines had a total trackage of 17.418 miles (28.032 km). Sidings and spurs aggregated 30.664 miles (49.349 km), and all tracks owned 94.574 miles (152.202 km).

Desloge Consolidated Lead Company was a lead mining company in the Southeast Missouri Lead District that was operated by the Desloge family in the 19th and early 20th century. The Desloge lead operations in the "Old Lead Belt", in the eastern Ozark Mountains, helped Missouri become the world's premier lead mining area.