The Mississippi State Bulldogs football program represents Mississippi State University in the sport of American football. The Bulldogs compete in the Football Bowl Subdivision (FBS) of the National Collegiate Athletic Association (NCAA) and the Western Division of the Southeastern Conference (SEC). They also have won one SEC championship in 1941 and a division championship in 1998. The Bulldogs have 26 postseason bowl appearances. The program has produced 38 All-Americans, 171 All-SEC selections, and 124 NFL players. The Bulldogs’ home stadium, Davis Wade Stadium at Scott Field, is the second oldest in the NCAA Division I FBS.

The Ole Miss Rebels football program represents the University of Mississippi, also known as "Ole Miss". The Rebels compete in the Football Bowl Subdivision (FBS) of the National Collegiate Athletic Association (NCAA) as members of the Southeastern Conference (SEC). The Rebels play their home games at Vaught–Hemingway Stadium on the university's campus in Oxford, Mississippi.