Mississippi State University for Agriculture and Applied Science, commonly known as Mississippi State University (MSU), is a public land-grant research university adjacent to Starkville, Mississippi. It is classified among "R1: Doctoral Universities – Very High Research Activity" and has a total research and development budget of $239.4 million, the largest in Mississippi.

Starkville is a city in, and the county seat of, Oktibbeha County, Mississippi, United States. Mississippi State University is a land-grant institution and is located partially in Starkville but primarily in an adjacent unincorporated area designated by the United States Census Bureau as Mississippi State, Mississippi. The population was 25,653 in 2019. Starkville is the most populous city of the Golden Triangle region of Mississippi. The Starkville micropolitan statistical area includes all of Oktibbeha County.