Missouri's 7th congressional district consists of Southwest Missouri. The district includes Springfield, the home of Missouri State University, the Joplin, Missouri, metropolitan area, Missouri's 5th largest, and the popular tourist destination city of Branson. Located along the borders of Kansas, Oklahoma, and Northwest Arkansas, the district occupies part of the Bible Belt with a strong socially conservative trend. George W. Bush defeated John Kerry here 67% to 32% in the 2004 election. Republican John McCain defeated Democrat Barack Obama 63.1% to 35.3% in the 2008 election. Republican and Former Massachusetts Governor Mitt Romney defeated Barack Obama 67.6% to 30.3% in the 2012 election. In the 2020 election, Republican Donald Trump defeated Democrat Joe Biden 69.91% to 28.93%. As of 2020, this district is the second most strongly Republican district in Missouri and is one of the most strongly Republican districts in the United States.

Eric Wayne Burlison is an American politician serving as the U.S. representative from Missouri's 7th congressional district since 2023. He previously served as the representative for District 133 in the Missouri House of Representatives. A Republican, Burlison was elected to the Missouri House in 2008 and left office at the end of 2016. In 2018, he was elected to the Missouri Senate, representing District 20. He was elected to Congress in 2022.