Missouri's 7th congressional district consists of Southwest Missouri. The district includes Springfield, the home of Missouri State University, the Joplin, Missouri, metropolitan area, Missouri's 5th largest, and the popular tourist destination city of Branson. Located along the borders of Kansas, Oklahoma, and Northwest Arkansas, the district occupies part of the Bible Belt with a strong socially conservative trend. George W. Bush defeated John Kerry here 67% to 32% in the 2004 election. Republican John McCain defeated Democrat Barack Obama 63.1% to 35.3% in the 2008 election. Republican and Former Massachusetts Governor Mitt Romney defeated Barack Obama 67.6% to 30.3% in the 2012 election. In the 2020 election, Republican Donald Trump defeated Democrat Joe Biden 69.91% to 28.93%. As of 2020, this district is the second most strongly Republican district in Missouri and is one of the most strongly Republican districts in the United States.

Missouri's third congressional district is in the eastern and central portion of the state. It stretches from the southern part of Columbia and the state capital of Jefferson City in the west to St. Charles County and western Jefferson County in the east. The district took its current form in 2023, when Cooper and parts of Boone counties were added to the district, while Franklin and most of Warren counties were instead drawn into the 2nd district. Its current representative is Republican Blaine Luetkemeyer.