The Missouri Compromise was a federal legislation of the United States that balanced desires of northern states to prevent the expansion of slavery in the country with those of southern states to expand it. It admitted Missouri as a slave state and Maine as a free state and declared a policy of prohibiting slavery in the remaining Louisiana Purchase lands north of the 36°30′ parallel. The 16th United States Congress passed the legislation on March 3, 1820, and President James Monroe signed it on March 6, 1820.

The Louisiana Purchase was the acquisition of the territory of Louisiana by the United States from the French First Republic in 1803. This consisted of most of the land in the Mississippi River's drainage basin west of the river. In return for fifteen million dollars, or approximately eighteen dollars per square mile, the United States nominally acquired a total of 828,000 sq mi in Middle America. However, France only controlled a small fraction of this area, most of which was inhabited by Native Americans; effectively, for the majority of the area, the United States bought the preemptive right to obtain Indian lands by treaty or by conquest, to the exclusion of other colonial powers.