The Missouri Republican Party is the affiliate of the United States Republican Party in Missouri. Its chair is Nick Myers, who has served since 2021. It is currently the dominant party in the state, controlling the majority of Missouri's U.S. House seats, both U.S. Senate seats, both houses of the state legislature, and all statewide offices, including the governorship.

The Missouri General Assembly is the state legislature of the U.S. state of Missouri. The bicameral General Assembly is composed of a 34-member Senate and a 163-member House of Representatives. Members of both houses of the General Assembly are subject to term limits. Senators are limited to two four-year terms and representatives to four two-year terms, a total of 8 years for members of both houses.