The Missouri Rhineland is a German cultural region of Missouri that extends from west of St. Louis to slightly east of Jefferson City, located mostly in the Missouri River Valley on both sides of the river. Dutzow, the first permanent German settlement in Missouri, was founded in 1832 by an immigrant from Lübeck, the "Baron" Johann Wilhelm von Bock. The area was named by Rhinelanders who noticed its similarities in soil and topography to the Rhineland region of Europe, a wine-growing area around the Rhine river. Rhinelanders settled the region, along with other Germans; by 1860, nearly half of all settlers in Missouri Rhineland were from Koblenz, capital of the Rhine Province.

Missouri is a landlocked state in the Midwestern region of the United States. Ranking 21st in land area, it borders Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas to the south and Oklahoma, Kansas, and Nebraska to the west. In the south are the Ozarks, a forested highland, providing timber, minerals, and recreation. The Missouri River, after which the state is named, flows through the center and into the Mississippi River, which makes up the eastern border. With over six million residents, it is the 18th-most populous state of the country. The largest urban areas are St. Louis, Kansas City, Springfield, and Columbia; the capital is Jefferson City.