Mistawasis was a Chief of the Sak-kaw-wen-o-wak Plains Cree, notable for his role as the leader of his people during the signing of Treaty 6 in 1876, to which he was the first signatory. Due to the dwindling buffalo population caused by excessive hunting, he was forced to look for new strategies to ensure the survival of his people and their culture. He believed the only way to save his people was to negotiate with the Canadian Government. As a result of his strong influence over the Cree people, he and his close ally Ahtahkakoop were able to argue successfully for the adoption of Treaty 6 by his fellow Cree. After the treaty was signed he remained an ally of the Canadian government until his death.

The Chief Mistawasis Bridge is a girder bridge in Saskatoon, Saskatchewan. The bridge officially opened on Oct. 2, 2018, and extends McOrmond Drive across the South Saskatchewan River to connect to Marquis Drive, providing a commuter bypass connecting communities on Saskatoon's northeast and eastern sides more directly to industrial and business development on the city's north. Construction of this bridge, located in the northern portion of the city, was financed in concert with construction of replacement for the 1907 Traffic Bridge in the downtown core, which was closed in 2010; that project was opened to traffic on October 3, 2018.