Misterioso is a 1958 live album by American jazz ensemble the Thelonious Monk Quartet. By the time of its recording, the pianist and bandleader Thelonious Monk had overcome an extended period of career difficulties and achieved stardom with his residency at New York's Five Spot Café, beginning in 1957. He returned there the following year for a second stint with his quartet, featuring drummer Roy Haynes, bassist Ahmed Abdul-Malik, and tenor saxophonist Johnny Griffin. Along with Thelonious in Action (1958), Misterioso captures portions of the ensemble's August 7 show at the venue.

The Five Spot Café was a jazz club located at 5 Cooper Square (1956–1962) in the Bowery neighborhood of New York City, between the East and West Village. In 1962, it moved to 2 St. Marks Place until closing in 1967. Its friendly, non-commercial, and low-key atmosphere with affordable drinks and food and cutting edge bebop and progressive jazz attracted a host of avant-garde artists and writers. It was a venue of historic significance as well, a mecca for musicians, both local and out-of-state, who packed the small venue to listen to many of the most creative composers and performers of the era.