Mitchell River National Park is a national park in the Kimberley region of Western Australia, 2,140 kilometres (1,330 mi) northeast of Perth. The park adjoins the northern boundary of the Prince Regent National Park. The nearest towns are Derby, 350 kilometres (217 mi) to the southwest, as well as Wyndham, 270 km (168 mi) to the southeast. Created in 2000, the park covers an area of over 1,150 km2 (440 sq mi) on the Mitchell Plateau (Ngauwudu).

The Kimberley is the northernmost of the nine regions of Western Australia. It is bordered on the west by the Indian Ocean, on the north by the Timor Sea, on the south by the Great Sandy and Tanami deserts in the region of the Pilbara, and on the east by the Northern Territory.