Mitla is the second-most important archeological site in the state of Oaxaca in Mexico, and the most important of the Zapotec culture. The site is located 44 km from the city of Oaxaca, in the upper end of the Tlacolula Valley, one of the three cold, high valleys that form the Central Valleys Region of the state. At an elevation of 4,855 ft, surrounded by the mountains of the Sierra Madre del Sur, the archeological site is within the modern municipality of San Pablo Villa de Mitla. It is 24 mi (38 km) southeast of Oaxaca city. While Monte Albán was the most important politically of the Zapotec centers, Mitla became the main religious one in a later period as the area became dominated by the Mixtec.

Oaxaca, officially the Free and Sovereign State of Oaxaca, is one of the 32 states that compose the Federative Entities of the United Mexican States. It is divided into 570 municipalities, of which 418 are governed by the system of usos y costumbres with recognized local forms of self-governance. Its capital city is Oaxaca de Juárez.