Mobeetie is a city in northwestern Wheeler County, Texas, United States, located on Sweetwater Creek and State Highway 152. Its population was 101 at the 2010 census, six below the 2000 figure.

Wheeler County is a county located in the U.S. state of Texas. As of the 2020 census, its population was 4,990. Its county seat is Wheeler. The county was formed in 1876 and organized in 1879. It is named for Royall Tyler Wheeler, a chief justice of the Texas Supreme Court.