Mobile County Public School System (MCPSS) is a school district based in unincorporated Mobile County, Alabama, United States. The system currently serves areas of Mobile County, including the city of Mobile, with the exception of the cities of Saraland, Satsuma and Chickasaw. Saraland voted to separate its schools from Mobile County in 2006, with Satsuma and Chickasaw following suit in 2012. The system serves urban, suburban, and rural areas. All schools in the system are required to adopt school uniform policies. It is the largest school system in Alabama and the 71st largest school system in the United States.

Mobile County is located in the southwestern corner of the U.S. state of Alabama. It is the third-most populous county in the state after Jefferson and Madison counties. As of the 2020 census, its population was 414,809. Its county seat is Mobile, which was founded as a deepwater port on the Mobile River. The only such port in Alabama, it has long been integral to the economy for providing access to inland waterways as well as the Gulf of Mexico.