The Moccasin Bluff site is an archaeological site located along the Red Bud Trail and the St. Joseph River north of Buchanan, Michigan. It was listed on the National Register of Historic Places in 1977, and has been classified as a multi-component prehistoric site with the major component dating to the Late Woodland/Upper Mississippian period.

Buchanan is a city in Berrien County in the U.S. state of Michigan. The population was 4,300 at the 2020 census. The city is located at the southeast corner of Buchanan Township, about 5 miles (8.0 km) west of Niles.