A mojo, in the African-American spiritual practice called Hoodoo, is an amulet consisting of a flannel bag containing one or more magical items. It is a "prayer in a bag", or a spell that can be carried with or on the host's body. Alternative American names for the mojo bag include gris-gris bag, hand, mojo hand, toby, nation sack, conjure hand, lucky hand, conjure bag, juju bag, trick bag, tricken bag, root bag, and jomo. The word mojo also refers to magic and charms. Mojo containers are bags, gourds, bottles, shells, and other containers. The making of mojo bags in Hoodoo is a system of African-American occult magic. The creation of mojo bags is an esoteric system that involves sometimes housing spirits inside of bags for either protection, healing, or harm and to consult with spirits. Other times mojo bags are created to manifest results in a person's life such as good-luck, money or love.

Hoodoo is a set of spiritual practices, traditions, and beliefs that were created by enslaved African Americans in the Southern United States from various traditional African spiritualities and elements of indigenous botanical knowledge. Practitioners of Hoodoo are called rootworkers, conjure doctors, conjure men or conjure women, and root doctors. Regional synonyms for Hoodoo include rootwork and conjure. As a syncretic spiritual system, it also incorporates beliefs from Islam brought over by enslaved West African Muslims, and Spiritualism. Scholars define Hoodoo as a folk religion. It is a syncretic religion between two or more cultural religions, in this case being African indigenous spirituality and Abrahamic religion.