Moldova participated in the Eurovision Song Contest 2010 with the song "Run Away" written by Anton Ragoza, Sergey Stepanov and Alina Galetskaya. The song was performed by the group SunStroke Project and Olia Tira. The Moldovan broadcaster TeleRadio-Moldova (TRM) organised the national final O melodie pentru Europa 2010 in order to select the Moldovan entry for the 2010 contest in Oslo, Norway. 83 entries competed to represent Moldova in Oslo, with 30 being shortlisted to participate in the televised national final. After two semi-finals and a final which took place in February and March 2010, "Run Away" performed by SunStroke Project and Olia Tira emerged as the winner after gaining the most points following the combination of votes from a jury panel and a public televote.

Cyprus participated in the Eurovision Song Contest 2010 with the song "Life Looks Better in Spring" written by Nasos Lambrianides and Melis Konstantinou. The song was performed by Jon Lilygreen and the Islanders. The Cypriot broadcaster Cyprus Broadcasting Corporation (CyBC) organised the national final Eurovision 2010: Epilogi tis kypriakis symmetochis in order to select the Cypriot entry for the 2010 contest in Oslo, Norway. The national final featured nine entries, resulting in the selection of Lilygreen and the Islanders with "Life Looks Better in Spring" at the final in February 2010.