Mole Creek Karst is a national park situated in the North of Tasmania, Australia, 168 km northwest of Hobart. It is located on the slopes of the Great Western Tiers to the east of the town of Mole Creek. It is the only national park in Tasmania created specifically to protect karst landforms. It is part of the Tasmanian Wilderness World Heritage Site.

The Tasmanian Wilderness World Heritage Area, abbreviated to TWWHA, is a World Heritage Site in Tasmania, Australia. It is one of the largest conservation areas in Australia, covering 15,800 km2 (6,100 sq mi), or almost 25 per cent of Tasmania. It is also one of the last expanses of temperate wilderness in the world, and includes the South West Wilderness.