The Royal Monastery of Saint Mary of Guadalupe is a Roman Catholic monastic establishment built during the 14th century located in Guadalupe, in Extremadura, Spain. It is located at the foot of the eastern side of the Sierra de las Villuercas and was one of the most important and fine monasteries in the country for more than four centuries. UNESCO declared it a World Heritage Site in 1993.

Our Lady of Guadalupe in Extremadura is a Marian shrine in Cáceres, Spain that traces its history to the medieval kingdom of Castile. The image is enshrined in the Monastery of Santa María de Guadalupe, in the Extremadura autonomous community of Spain, and is considered the most important Marian shrine in the country.