Montezuma National Wildlife Refuge is a wildlife preserve operated by the United States Fish and Wildlife Service, encompassing part of the Montezuma Swamp at the north end of Cayuga Lake. The 10,004-acre preserve is composed of swamps, pools and channels and is a stopping point for migratory birds. It is the largest contiguous wetland complex in the northeastern United States and comprises a portion of the larger Montezuma Wetlands Complex, which is a partnership between the USFWS, the New York State Department of Environmental Conservation, as well as several other non-profit support organizations.

Cayuga Lake is the longest of central New York's glacial Finger Lakes, and is the second largest in surface area and second largest in volume. It is just under 39 miles (63 km) long. Its average width is 1.7 miles (2.8 km), and it is 3.5 mi wide (5.6 km) at its widest point, near Aurora. It is approximately 435 ft deep (133 m) at its deepest point, and has over 95 miles (153 km) of shoreline.