Monticello is a city in Wayne County, Kentucky, in the United States. It is the seat of its county. The population was 6,188 at the time of the 2010 U.S. census.

Wayne County is a county in the U.S. state of Kentucky along the southern border with Tennessee. As of the 2020 census, the population was 19,555. Its county seat is Monticello. The county, on the south-central border with Tennessee, was named for Gen. Anthony Wayne, a Revolutionary War hero. As of November 3, 2020, Wayne County is a wet county—a measure allowing the sales and consumption of alcoholic drinks passed by a margin of 4,901 for and 3,966 against.