The Montreal Laboratory was a program established by the National Research Council of Canada during World War II to undertake nuclear research in collaboration with the United Kingdom, and to absorb some of the scientists and work of the Tube Alloys nuclear project in Britain. It became part of the Manhattan Project, and designed and built some of the world's first nuclear reactors.

Jordan Carson Mark was a Canadian-American mathematician best known for his work on developing nuclear weapons for the United States at the Los Alamos National Laboratory. Mark joined the Manhattan Project in 1945, and continued to work at Los Alamos under the leadership of Norris Bradbury after World War II ended. He became the leader of the Theoretical Division at the laboratory in 1947, a position he held until 1973. He oversaw the development of new weapons, including the hydrogen bomb in the 1950s. On the hydrogen bomb project he was able to bring together experts like Edward Teller, Stanislaw Ulam and Marshall Holloway despite their personal differences.