Montrose is a home rule municipality that is the county seat and the most populous municipality of Montrose County, Colorado, United States. The city population was 20,291 at the 2020 census, within a total area of 18.5 square miles. The main road that leads in and out of Montrose is U.S. Highway 50. The city is located in western Colorado, in the Uncompahgre Valley, and is an economic, labor, and transportation waypoint for the surrounding area. Montrose is the second-largest city in western Colorado, after Grand Junction.

A Legend of Montrose is an historical novel by Sir Walter Scott, set in Scotland in the 1640s during the Wars of the Three Kingdoms. It forms, along with The Bride of Lammermoor, the 3rd series of Scott's Tales of My Landlord. The two novels were published together in 1819.