The Morello crime family was one of the earliest crime families to be established in the United States and New York City. The Morellos were based in Manhattan's Italian Harlem and eventually gained dominance in the Italian underworld by defeating the rival Neapolitan Camorra of Brooklyn. They were the predecessors of what eventually became known as the Genovese crime family.

The Genovese crime family, also sometimes referred to as the Westside, is an Italian-American Mafia crime family and one of the "Five Families" that dominate organized crime activities in New York City and New Jersey as part of the American Mafia. They have generally maintained a varying degree of influence over many of the smaller mob families outside New York, including ties with the Philadelphia, Patriarca, and Buffalo crime families.